Correlating the transcriptome, proteome, and metabolome in the environmental adaptation of a hyperthermophile.

@article{Trauger2008CorrelatingTT,
  title={Correlating the transcriptome, proteome, and metabolome in the environmental adaptation of a hyperthermophile.},
  author={S. Trauger and Ewa Kalisak and J. Kalisiak and H. Morita and Michael V Weinberg and A. Menon and F. Poole and M. Adams and G. Siuzdak},
  journal={Journal of proteome research},
  year={2008},
  volume={7 3},
  pages={
          1027-35
        }
}
We have performed a comprehensive characterization of global molecular changes for a model organism Pyrococcus furiosus using transcriptomic (DNA microarray), proteomic, and metabolomic analysis as it undergoes a cold adaptation response from its optimal 95 to 72 degrees C. Metabolic profiling on the same set of samples shows the down-regulation of many metabolites. However, some metabolites are found to be strongly up-regulated. An approach using accurate mass, isotopic pattern, database… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Variation among species in proteomic sulphur content is related to environmental conditions
  • 34
  • PDF
Unique polyamines produced by an extreme thermophile, Thermus thermophilus
  • 71
Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics*
  • 5,072
  • PDF
...
1
2
3
...