Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis

  title={Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis},
  author={R. Raheja and K. Regev and B. Healy and M. A. Mazzola and Vanessa Beynon and F. von Glehn and Anu Paul and C. D{\'i}az-Cruz and T. Gholipour and B. Glanz and P. Kivisakk and T. Chitnis and H. Weiner and James D. Berry and R. Gandhi},
  journal={Muscle & Nerve},
  • R. Raheja, K. Regev, +12 authors R. Gandhi
  • Published 2018
  • Medicine
  • Muscle & Nerve
  • Introduction: Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. Methods: We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzheimer disease. We also correlated miRNA expression in cross‐sectional and longitudinal cohorts of ALS patients with clinical parameters. Results: We identified 7 miRNAs (miR‐192‐5p… CONTINUE READING
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