Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes

@inproceedings{Caselle2001CorrelatingOU,
  title={Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes},
  author={Michele Caselle and Ferdinando Di Cunto and Paolo Provero},
  booktitle={BMC Bioinformatics},
  year={2001}
}
Gene regulation in eukaryotes is mainly effected through transcription factors binding to rather short recognition motifs generally located upstream of the coding region. We present a novel computational method to identify regulatory elements in the upstream region of eukaryotic genes. The genes are grouped in sets sharing an overrepresented short motif in their upstream sequence. For each set, the average expression level from a microarray experiment is determined: If this level is… CONTINUE READING
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Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes

  • M Caselle, F Di Cunto, P Provero
  • BMC Bioinformatics 2002,
  • 2002
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