Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623.

@article{McEvoy2017CorrelatingIV,
  title={Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623.},
  author={Claire L. McEvoy and Natalie L. Trevaskis and O. Feeney and G. Edwards and M. Perlman and C. Ambler and C. J. Porter},
  journal={Molecular pharmaceutics},
  year={2017},
  volume={14 12},
  pages={
          4525-4538
        }
}
Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-soluble drugs and have been shown previously to enhance the oral exposure of CP-532,623, an oral cholesteryl ester transfer protein inhibitor. In the current study, an in vitro lipid digestion model was used to probe the relationship between drug solubilization and supersaturation on in vitro dispersion and digestion of LBF containing long chain (LC) lipids and drug absorption in vivo. After in vitro… Expand
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