Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer.

@article{Vukovic2007CorrelatingBE,
  title={Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer.},
  author={Bisera Vukovic and Ben Beheshti and Paul M Park and Gloria Lim and Jane M Bayani and Maria Zielenska and Jeremy A Squire},
  journal={Cytogenetic and genome research},
  year={2007},
  volume={116 1-2},
  pages={1-11}
}
Chromosomal instability (CIN) is thought to underlie the generation of chromosomal changes and genomic heterogeneity during prostatic tumorigenesis. The breakage-fusion-bridge (BFB) cycle is one of the CIN mechanisms responsible for characteristic mitotic abnormalities and the occurrence of specific classes of genomic rearrangements. However, there is little detailed information concerning the role of BFB and CIN in generating genomic diversity in prostate cancer. In this study we have used… CONTINUE READING

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