Correlates of vaccine protection from influenza and its complications.

@article{McCullers2012CorrelatesOV,
  title={Correlates of vaccine protection from influenza and its complications.},
  author={Jonathan A. McCullers and Victor C. Huber},
  journal={Human vaccines & immunotherapeutics},
  year={2012},
  volume={8 1},
  pages={34-44}
}
Despite use of influenza vaccines for more than 65 y, influenza and its complications are a major cause of morbidity and mortality worldwide. Most deaths during influenza virus infections are due to underlying co-morbidities or secondary bacterial pneumonia. The measures of immune response currently used for licensure of influenza vaccines are relevant mainly for protection from viral infection in healthy adults. Development of new or improved influenza vaccines will require a definition of… CONTINUE READING
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