Correlates of sleep and waking in Drosophila melanogaster.

@article{Shaw2000CorrelatesOS,
  title={Correlates of sleep and waking in Drosophila melanogaster.},
  author={P. Shaw and C. Cirelli and R. Greenspan and G. Tononi},
  journal={Science},
  year={2000},
  volume={287 5459},
  pages={
          1834-7
        }
}
Drosophila exhibits a circadian rest-activity cycle, but it is not known whether fly rest constitutes sleep or is mere inactivity. It is shown here that, like mammalian sleep, rest in Drosophila is characterized by an increased arousal threshold and is homeostatically regulated independently of the circadian clock. As in mammals, rest is abundant in young flies, is reduced in older flies, and is modulated by stimulants and hypnotics. Several molecular markers modulated by sleep and waking in… Expand

Paper Mentions

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