Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques.

@article{Kurupati2013CorrelatesOR,
  title={Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques.},
  author={Raj Kumar Kurupati and Steve Tuyishime and Andrew V. Kossenkov and Marina Sazanovich and Larissa Herkenhoff Haut and Marcio de Oliveira Lasaro and Sarah J. Ratcliffe and Steven E Bosinger and Diane G. Carnathan and Mark Lewis and Louise C. Showe and Guido Silvestri and Hildegund C. J. Ertl},
  journal={Journal of leukocyte biology},
  year={2013},
  volume={93 3},
  pages={437-48}
}
In this study, we compared the immunogenicity and protection from repeated low-dose intrarectal SIVmac251 challenge in two groups of vaccinated RMs. Animals were immunized with live SIVmac239, which had been attenuated by a deletion of the nef sequence, or they were vaccinated twice with an E1-deleted AdHu5, expressing SIVmac239gag. The vaccinated animals and a cohort of unvaccinated control animals were then challenged 10 times in weekly intervals with low doses of SIVmac251 given rectally… CONTINUE READING