Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment.

@article{Wodarz2000CorrelatesOC,
  title={Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment.},
  author={Dominik Wodarz and Martin A. Nowak},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2000},
  volume={355 1400},
  pages={1059-70}
}
A very important question in immunology is to determine which factors decide whether an immune response can efficiently clear or control a viral infection, and under what circumstances we observe persistent viral replication and pathology. This paper summarizes how mathematical models help us gain new insights into these questions, and explores the relationship between antiviral therapy and long-term immunological control in human immunodeficiency virus (HIV) infection. We find that cytotoxic T… CONTINUE READING

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