Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine

@inproceedings{Wright2016CorrelatesOI,
  title={Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine},
  author={Peter Farnum Wright and Anne Gatewood Hoen and Natalia A Ilyushina and Eric P. Brown and Margaret E. Ackerman and Wendy F Wieland-Alter and Ruth I. Connor and Sinthujan Jegaskanda and Yael Rosenberg-Hasson and Brenda C. Haynes and Catherine J. Luke and Kanta Subbarao and John Jay Treanor},
  booktitle={Open forum infectious diseases},
  year={2016}
}
Background.  The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children. Methods.  Serum and mucosal responses to LAIV or IIV were analyzed using immunologic assays to assess both quantitative and functional responses. Cytokines and chemokines were… CONTINUE READING
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Recommenda - tions for prevention and control of in fl uenza in children , 2014 - 2015

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