Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.

@article{BeckelMitchener2004CorrelatesAT,
  title={Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.},
  author={Andrea Beckel-Mitchener and William T. Greenough},
  journal={Mental retardation and developmental disabilities research reviews},
  year={2004},
  volume={10 1},
  pages={53-9}
}
Fragile X syndrome (FXS) is characterized by a pattern of morphological, functional, and molecular characteristics with, in at least some cases, apparent relationships among phenotypic features at different levels. Gross morphology differences in the sizes of some human brain regions are accompanied by fine structural alterations in the shapes and in the numbers of dendritic spines in both humans and the knockout mouse model. The excess number of spines, their immature appearance, and the… CONTINUE READING

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