Correlated variability modifies working memory fidelity in primate prefrontal neuronal ensembles.

@article{Leavitt2017CorrelatedVM,
  title={Correlated variability modifies working memory fidelity in primate prefrontal neuronal ensembles.},
  author={Matthew L. Leavitt and Florian Pieper and Adam Sachs and Julio C. Martinez-Trujillo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 12},
  pages={E2494-E2503}
}
Neurons in the primate lateral prefrontal cortex (LPFC) encode working memory (WM) representations via sustained firing, a phenomenon hypothesized to arise from recurrent dynamics within ensembles of interconnected neurons. Here, we tested this hypothesis by using microelectrode arrays to examine spike count correlations (rsc ) in LPFC neuronal ensembles during a spatial WM task. We found a pattern of pairwise rsc during WM maintenance indicative of stronger coupling between similarly tuned… CONTINUE READING

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