Correlated mutations and residue contacts in proteins

@article{Gbel1994CorrelatedMA,
  title={Correlated mutations and residue contacts in proteins},
  author={Uwe G{\"o}bel and Chris Sander and Reinhard Schneider and Alfonso Valencia},
  journal={Proteins: Structure},
  year={1994},
  volume={18}
}
The maintenance of protein function and structure constrains the evolution of amino acid sequences. This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical contact in three dimensions. Here we present a simple and general method to analyze correlations in mutational behavior between different positions in a multiple sequence alignment. We then use these correlations to predict contact maps for each of 11 protein families… Expand
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