Correlated fluctuations carry signatures of gene regulatory network dynamics.

@article{Pakka2010CorrelatedFC,
  title={Correlated fluctuations carry signatures of gene regulatory network dynamics.},
  author={Vijayanarasimha H. Pakka and Adam Pr{\"u}gel-Bennett and Srinandan Dasmahapatra},
  journal={Journal of theoretical biology},
  year={2010},
  volume={266 3},
  pages={
          343-57
        }
}
The dynamics of transcriptional control involve small numbers of molecules and result in significant fluctuations in protein and mRNA concentrations. The correlations between these intrinsic fluctuations then offer, via the fluctuation dissipation relation, the possibility of capturing the system's response to external perturbations, and hence the nature of the regulatory activity itself. We show that for simple regulatory networks of activators and repressors, the correlated fluctuations… CONTINUE READING
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