Correlated evolution of interacting proteins: looking behind the mirrortree.

  title={Correlated evolution of interacting proteins: looking behind the mirrortree.},
  author={Maricel G. Kann and Benjamin A. Shoemaker and Anna R. Panchenko and Teresa M. Przytycka},
  journal={Journal of molecular biology},
  volume={385 1},
It has been observed that the evolutionary distances of interacting proteins often display a higher level of similarity than those of noninteracting proteins. This finding indicates that interacting proteins are subject to common evolutionary constraints and constitutes the basis of a method to predict protein interactions known as mirrortree. It has been difficult, however, to identify the direct cause of the observed similarities between evolutionary trees. One possible explanation is the… CONTINUE READING