• Corpus ID: 248449611

Correlated alterations in genome organization, histone Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson- methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome Gilford progeria

@inproceedings{CorrelatedAI,
  title={Correlated alterations in genome organization, histone Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson- methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome Gilford progeria},
  author={}
}
  • Biology
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA . This mutation activates a cryptic splice donor site in exon 11, and leads to an in-frame deletion within the prelamin A mRNA and the production of a dominant-negative lamin A protein, known as progerin. Here we show that primary HGPS skin fibroblasts experience genome-wide correlated alterations in patterns of H3K27me3 deposition, DNA-lamin A… 

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