Correctors promote folding of the CFTR in the endoplasmic reticulum.

@article{Loo2008CorrectorsPF,
  title={Correctors promote folding of the CFTR in the endoplasmic reticulum.},
  author={T. Y. Wings Loo and M. Claire Bartlett and David R. Clarke},
  journal={The Biochemical journal},
  year={2008},
  volume={413 1},
  pages={29-36}
}
Cystic fibrosis (CF) is most commonly caused by deletion of a residue (DeltaF508) in the CFTR (cystic fibrosis transmembrane conductance regulator) protein. The misfolded mutant protein is retained in the ER (endoplasmic reticulum) and is not trafficked to the cell surface (misprocessed mutant). Corrector molecules such as corr-2b or corr-4a are small molecules that increase the amount of functional CFTR at the cell surface. Correctors may function by stabilizing CFTR at the cell surface or by… CONTINUE READING
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