Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector.

@article{Serratrice2014CorrectiveGT,
  title={Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector.},
  author={Nicolas Serratrice and Aur{\'e}lie Cubizolle and Sandy Ibanes and Nadine Mestre-Franc{\'e}s and Neus Bayo-Puxan and Sophie Creyssels and Aur{\'e}lie Gennetier and Florence Bernex and Jean-Michel Verdier and Mark E. Haskins and Guilhem Couderc and François J Malecaze and Vasiliki Kalatzis and Eric J Kremer},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={181},
  pages={22-31}
}
Corneal transparency is maintained, in part, by specialized fibroblasts called keratocytes, which reside in the fibrous lamellae of the stroma. Corneal clouding, a condition that impairs visual acuity, is associated with numerous diseases, including mucopolysaccharidosis (MPS) type VII. MPS VII is due to deficiency in β-glucuronidase (β-glu) enzymatic activity, which leads to accumulation of glycosaminoglycans (GAGs), and secondary accumulation of gangliosides. Here, we tested the efficacy of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS