Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.

Abstract

Cells from a subset of patients with the DNA-repair-defective disease xeroderma pigmentosum complementation group E (XP-E) are known to lack a DNA damage-binding (DDB) activity. Purified human DDB protein was injected into XP-E cells to test whether the DNA-repair defect in these cells is caused by a defect in DDB activity. Injected DDB protein stimulated… (More)

5 Figures and Tables

Topics

  • Presentations referencing similar topics