Correction of perfusate concentration for sample removal.

@article{Hayton1982CorrectionOP,
  title={Correction of perfusate concentration for sample removal.},
  author={W. Hayton and T. M. Chen},
  journal={Journal of pharmaceutical sciences},
  year={1982},
  volume={71 7},
  pages={
          820-1
        }
}
  • W. Hayton, T. Chen
  • Published 1 July 1982
  • Biology
  • Journal of pharmaceutical sciences
Repeated sampling of a drug solution that is recirculated through a perfused body increases the rate of drug disappearance from the perfusate. When the volume of the drug solution (VT) is maintained constant by addition of drug-free perfusate after sampling, the measured drug concentration (Ci) can be corrected for drug removed in previous samples by using the equation C'i = CiVTC'i-1/(VT - VS)Ci-1, where C'i is the corrected drug concentration in the ith sample, VS is the volume of the sample… 
Evaluation of Passive and Iontophoretic Transport of Lisinopril from Hydrogel Matrix Across Model Membrane In Vitro
TLDR
Investigations were carried out to ascertain the relative importance of the various factor for iontophoretic transport using an ionizable drug lisinopril, which has four pKa values 2.4, 4.0 and 7.0, and cathodal and cathODal current at varied pH of donor solution and current densities.
Effect of the solvent system on the in vitro permeability of nicardipine hydrochloride through excised rat epidermis.
  • Y. Krishnaiah, V. Satyanarayana, R. Karthikeyan
  • Chemistry
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2002
TLDR
The results of the study indicate that the use of a binary solvent system, ethanol and water in the ratio of 70:30 v/v, is an effective vehicle for the development of a transdermal therapeutic system for nicardipine hydrochloride.
Bioavailability of nerodilol-based transdermal therapeutic system of nicorandil in human volunteers.
Enhanced Percutaneous Permeability of Nicardipine Hydrochloride by Carvone Across the Rat Abdominal Skin
TLDR
It is suggested that carvone may be useful for enhancing the skin permeability of nicardipine hydrochloride from transdermal therapeutic system containing HPC gel as a reservoir.
EFFECT OF TERNARY SOLVENT SYSTEM ON THEPERMEABILITY OF LISINOPRIL ACROSS RAT SKIN IN VITRO
Investigation were carried out on the permeation of lisinopril across excised rat skin for selecting a suitable solvent system for the development of a topical gel formulation. The solubility of
In vitro percutaneous permeability enhancement of nimodipine by limonene across the excised rat abdominal skin.
TLDR
Investigation of in vitro permeation of nimodipine across the excised rat abdominal skin from a 2% w/w hydroxypropyl methylcellulose gel drug reservoir system suggests that limonene is useful for enhancing the skin permeability from transdermal therapeutic systems containing HPMC gel as a reservoir.
Transepidermal Transport Enhancement of Insulin by Lipid Extraction and Iontophoresis
TLDR
The SC lipid extraction using suitable solvents followed by iontophoresis can synergistically enhance the transepidermal transport of insulin.
1 1 Iontophoretic Drug Delivery
TLDR
Most preferred route is the oral route among the various routes of drug delivery, which bypass the hepatic “first-pass’’ elimination and also maintain a constant, prolonged, and therapeutically-effective drug level in the body.
...
1
2
3
4
5
...

References

SHOWING 1-5 OF 5 REFERENCES
Comparative pharmacokinetics of coumarin anticoagulants. 3. Factors affecting the distribution and elimination of bishydroxycoumarin (BHC) in isolated liver perfusion studies.
TLDR
It was found that the apparent rate constant for the metabolism of B HC in isolated perfused rat livers is affected by the initial concentration of drug and by the source and concentration of plasma proteins, and that it is a function mainly of the distribution of BHC between liver and plasma.
Renal clearance of salicylic acid and salicyluric acid in the rat and in the isolated perfused rat kidney.
TLDR
The hypothesis that administered SA is cleared differently than SA formed from SU in the isolated perfused rat kidney is supported, presumably due to rate-limiting diffusion of SA into the cell.
Intestinal absorption mechanism of amphoteric beta-lactam antibiotics II: Michaelis-Menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats.
TLDR
Evidence from a pharmacokinetic analysis of steady-state blood concentrations after constant infusion ofcyclacillin through the portal vein and the small intestinal lumen indicated that cyclacillin absorption by the rat intestinal tissue at relatively low concentrations (less than 1 mg/ml) followed solely Michaelis-Menten kinetics.
An improved technique for perfusion of the guinea pig placenta in situ giving viable conditions demonstrated by placental transport of amino acids (L- and D-alanine).
An improved technique for perfusing the fetal guinea pig placenta in situ is described. The result shows linear pressure-flow relations in the rane of 15-50 mm Hg. assumed to be physiological. The