Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells

@article{Mavilio2006CorrectionOJ,
  title={Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells},
  author={Fulvio Mavilio and Graziella Pellegrini and Stefano Ferrari and Francesca di Nunzio and E. E. Di Iorio and Alessandra Recchia and Giulietta Maruggi and Giuliana Ferrari and Elena Provasi and Chiara Bonini and Sergio Capurro and Antonio Conti and Cristina Magnoni and Alberto Giannetti and Michele de Luca},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={1397-1402}
}
The continuous renewal of human epidermis is sustained by stem cells contained in the epidermal basal layer and in hair follicles. Cultured keratinocyte stem cells, known as holoclones, generate sheets of epithelium used to restore severe skin, mucosal and corneal defects. Mutations in genes encoding the basement membrane component laminin 5 (LAM5) cause junctional epidermolysis bullosa (JEB), a devastating and often fatal skin adhesion disorder. Epidermal stem cells from an adult patient… CONTINUE READING
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