Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

@article{Rossetti1987CorrectionOH,
  title={Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.},
  author={Luciano Rossetti and Darrin L. Smith and Gerald I Shulman and D N Papachristou and Ralph A DeFronzo},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={79 5},
  pages={
          1510-5
        }
}
Insulin resistance is characteristic of the diabetic state. To define the role of hyperglycemia in generation of the insulin resistance, we examined the effect of phlorizin treatment on tissue sensitivity to insulin in partially pancreatectomized rats. Five groups were studied: group I, sham-operated controls; group II, partially pancreatectomized diabetic rats with moderate glucose intolerance; group III, diabetic rats treated with phlorizin to normalize glucose tolerance; group IV, phlorizin… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 300 CITATIONS, ESTIMATED 45% COVERAGE

FILTER CITATIONS BY YEAR

1988
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 14 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Effect of insulin on renal potassium metabolism

  • D. Smith
  • Am . J . Physiol .
  • 1987

In vivo and in vitro resistance to maximal insulin stimulated glucose disposal in insulin deficiency

  • Y. Le Marchand-Brustel
  • Am . J . Physiol .
  • 1985