Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

@article{Rossetti1987CorrectionOH,
  title={Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.},
  author={L. Rossetti and D. Smith and G. Shulman and D. Papachristou and R. DeFronzo},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={79 5},
  pages={
          1510-5
        }
}
Insulin resistance is characteristic of the diabetic state. To define the role of hyperglycemia in generation of the insulin resistance, we examined the effect of phlorizin treatment on tissue sensitivity to insulin in partially pancreatectomized rats. Five groups were studied: group I, sham-operated controls; group II, partially pancreatectomized diabetic rats with moderate glucose intolerance; group III, diabetic rats treated with phlorizin to normalize glucose tolerance; group IV, phlorizin… Expand
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