Correction of cell–cell communication defect by introduction of a protein kinase into mutant cells

@article{Wiener1983CorrectionOC,
  title={Correction of cell–cell communication defect by introduction of a protein kinase into mutant cells},
  author={Erik C. Wiener and Werner R. Loewenstein},
  journal={Nature},
  year={1983},
  volume={305},
  pages={433-435}
}
The cell-to-cell permeability of the junctions of various cultured mammalian cell types depends on the concentration of intracellular cyclic AMP ([cAMP]i). The permeability rises when the cells are supplied with exogenous cyclic AMP or when their cyclic AMP synthesis is stimulated with choleragen or hormones; it falls when [cAMP]i is lowered by application of serum or due to increase in cell density1–5. The rise and fall in permeability take several hours to develop (the rise is protein… CONTINUE READING

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