Correction of acidosis in CAPD decreases whole body protein degradation.

@article{Graham1996CorrectionOA,
  title={Correction of acidosis in CAPD decreases whole body protein degradation.},
  author={Kenneth A Graham and David Reaich and S M Channon and S. J. Downie and E Gilmour and Jutta Passlick-Deetjen and Timothy H. J. Goodship},
  journal={Kidney international},
  year={1996},
  volume={49 5},
  pages={1396-400}
}
Correction of acidosis in CAPD decreases protein degradation and synthesis but has no effect on leucine oxidation. The effect of the correction of metabolic acidosis in CRF patients treated with CAPD was determined from the kinetics of infused L-[1-13C]leucine. Seven CAPD patients were studied before (acid) and after correction of acidosis (bicarbonate) (pH:acid 7.39 +/- 0.01, bicarbonate 7.41 +/- 0.01, P = 0.005). Leucine appearance from body protein (PD) [corrected] and leucine disappearance… CONTINUE READING

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