Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication.

@article{Yasaka2002CorrectionOI,
  title={Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication.},
  author={Masahiro Yasaka and Toshiyuki Sakata and Kazuo Minematsu and Hiroaki Naritomi},
  journal={Thrombosis research},
  year={2002},
  volume={108 1},
  pages={25-30}
}
We investigated the effect of prothrombin complex concentrate (PCC, median 500 IU) and vitamin K (10-20 mg) or either on blood coagulation and clinical findings in 17 patients with major hemorrhagic complication during warfarin treatment. Their international normalized ratio (INR) at admission was median 2.7 (2.0-above 10.0). In 11 patients treated with PCC and vitamin K, INR decreased to median 1.13 (0.91-1.36) 10 min after the administration with elevation of plasma levels of coagulant… CONTINUE READING