Correction of Hyperglycemia in Diabetic Mice Transplanted with Reversibly Immortalized Pancreatic β Cells Controlled by the tet-on Regulatory System.

@article{MiloLandesman2001CorrectionOH,
  title={Correction of Hyperglycemia in Diabetic Mice Transplanted with Reversibly Immortalized Pancreatic β Cells Controlled by the tet-on Regulatory System.},
  author={Dalit Milo-Landesman and Manju Surana and Irina Berkovich and Amelia Compagni and Gerhard Christofori and Norman Fleischer and Shimon Efrat},
  journal={Cell transplantation},
  year={2001},
  volume={10 7},
  pages={645-650}
}
Pancreatic β cell lines may offer an abundant source of cells for β-cell replacement in type I diabetes. Using regulatory elements of the bacterial tetracycline (tet) operon for conditional expression of SV40 T antigen oncoprotein in transgenic mouse β cells, we have shown that reversible immortalization is an efficient approach for regulated β-cell… CONTINUE READING