Correction: Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts

@article{Kuta2010CorrectionMC,
  title={Correction: Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts},
  author={Anna Kuta and Wenhan Deng and Ali S Morsi El-Kadi and Gareth T. Banks and Majid Hafezparast and Katherine Pfister and Elizabeth M. C. Fisher},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
Background: Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of eukaryotic cells. The cytoplasmic dynein complex is an important motor that moves cargos along microtubule tracks within the cell. In mammals this multiprotein complex includes dynein intermediate chains 1 and 2 which are encoded by two genes, Dync1i1 and Dync1i2. These proteins are involved in dynein cargo binding and dynein… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Increasing Alternative Promoter Repertories Is Positively Associated with Differential Expression and Disease Susceptibility
TLDR
The genome-wide analysis provided evidences that increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility and showed that genes with increased number of APs tend to have increased length in all aspects of gene structure and have increased connectivity in protein-protein interaction network. Expand
Conserved Usage of Alternative 5′ Untranslated Exons of the GATA4 Gene
TLDR
The results indicate that the GATA4 gene closely resembles the other GATA family members in terms of gene structure where alternative first exon usage appears to be an important mechanism for regulating its tissue- and cell-specific expression. Expand
Regulators of the cytoplasmic dynein motor
TLDR
It is found that a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport activities as the many different types of kinesin. Expand
The alternative noncoding exons 1 of aromatase (Cyp19) gene modulate gene expression in a posttranscriptional manner.
TLDR
An important role of the alternative exons 1 in posttranscriptional regulation of aromatase gene expression is uncovered, which is most likely due to a negative effect of certain alternative exon 1 on RNA stability and protein translation. Expand
Transfectioninduced defects in dynein-driven transport: evidence that ICs mediate cargobinding
  • Cell Motil Cytoskeleton
  • 2009
A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes
TLDR
Investigating the function of dynein variants, defined by different intermediate chain (IC) isoforms, by expressing fluorescent ICs in neuronal cells demonstrates that the IC isoforms define dyne in populations that are selectively recruited to transport distinct cargoes. Expand
Cytoplasmic dynein could be key to understanding neurodegeneration
A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorateExpand
DBTSS: database of transcription start sites, progress report 2008
TLDR
This update expanded the human transcriptional start site dataset by 19 million uniquely mapped, and RefSeq-associated, 5′-end sequences, which were generated by a newly introduced Solexa sequencer, and implemented two new analytical tools for connecting expression information with predicted transcription factor binding sites. Expand
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis
TLDR
Tandem mass spectrometry analysis of mitotic dynein revealed a phosphorylation site in the dyne in intermediate chains (ICs) that mediates binding to kinetochores, and suggests a new model for localization of Kinetochore Dynein and the contribution of kinet Cochore dynactin. Expand
Force-Induced Bidirectional Stepping of Cytoplasmic Dynein
TLDR
In the absence of ATP, dynein steps processively along microtubules under an external load, with less force required for minus-end- than for plus- end-directed movement, and nucleotide-independent walking reveals that force alone can drive repetitive microtubule detachment-attachment cycles of Dynein's motor domains. Expand
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