Correcting the expression of miRNA-155 represses PP2Ac and enhances the release of IL-2 in PBMCs of juvenile SLE patients.

@article{Lashine2015CorrectingTE,
  title={Correcting the expression of miRNA-155 represses PP2Ac and enhances the release of IL-2 in PBMCs of juvenile SLE patients.},
  author={Yasmine Adel Lashine and Samia Salah and Heba Ragaee Abdelhakam Aboelenein and Ahmed I Abdelaziz},
  journal={Lupus},
  year={2015},
  volume={24 3},
  pages={240-7}
}
MicroRNA-155 is involved in immune cell, differentiation, maturation and function. MiR-155 showed variable dysregulated expression in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. MiR-155 was previously confirmed to directly target CAMP response element binding protein (CREB), which was previously identified as a positive regulator of protein phosphatase 2A (PP2A). PP2A is a key negative regulator of interleukin-2, which is an important… CONTINUE READING
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