Correcting the QT interval for changes in HR in pre-clinical drug development.

@article{Meyners2004CorrectingTQ,
  title={Correcting the QT interval for changes in HR in pre-clinical drug development.},
  author={Michael Meyners and Michael Markert},
  journal={Methods of information in medicine},
  year={2004},
  volume={43 5},
  pages={445-50}
}
OBJECTIVES Estimation of possible cardiovascular side effects belongs to the safety assessment of every drug candidate. Drug-induced prolongation of the QT interval can result in life-threatening ventricular arrhythmia. In pre-clinical drug development, animal experiments are used to study this possible effect. Researchers have become aware that correction formulae derived for human beings are not applicable to animal experiments. METHODS We investigated some of the proposed models by… CONTINUE READING

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