Correcting temperature-sensitive protein folding defects.

@article{Brown1997CorrectingTP,
  title={Correcting temperature-sensitive protein folding defects.},
  author={C. Brown and L. Hong-Brown and W. Welch},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 6},
  pages={
          1432-44
        }
}
  • C. Brown, L. Hong-Brown, W. Welch
  • Published 1997
  • Medicine, Biology
  • The Journal of clinical investigation
  • Recently, we found that different low molecular weight compounds, all known to stabilize proteins in their native conformation, are effective in correcting the temperature-sensitive protein folding defect associated with the deltaF508 cystic fibrosis transmembrane regulator (CFTR) protein. Here we examined whether the folding of other proteins which exhibit temperature-sensitive folding defects also could be corrected via a similar strategy. Cell lines expressing temperature-sensitive mutants… CONTINUE READING
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