Correcting temperature-sensitive protein folding defects.

  title={Correcting temperature-sensitive protein folding defects.},
  author={Christopher R. Brown and Ly Q Hong-Brown and William J. Welch},
  journal={The Journal of clinical investigation},
  volume={99 6},
Recently, we found that different low molecular weight compounds, all known to stabilize proteins in their native conformation, are effective in correcting the temperature-sensitive protein folding defect associated with the deltaF508 cystic fibrosis transmembrane regulator (CFTR) protein. Here we examined whether the folding of other proteins which exhibit temperature-sensitive folding defects also could be corrected via a similar strategy. Cell lines expressing temperature-sensitive mutants… CONTINUE READING


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