Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival.

@article{Duffy2008CorrectingFL,
  title={Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival.},
  author={Stephen W. Duffy and Iris Nagtegaal and Matthew G. Wallis and Fay Helen Cafferty and Nehmat Houssami and Jane Warwick and Prue C. Allgood and Olive Kearins and Nancy Tappenden and Emma O'Sullivan and Gill Lawrence},
  journal={American journal of epidemiology},
  year={2008},
  volume={168 1},
  pages={98-104}
}
Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period. Assuming two latent categories of tumors, one of which is more prone to screen detection and correspondingly less prone to death from the cancer in question, the authors have developed a strategy of sensitivity analysis for various magnitudes of… CONTINUE READING

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