Correct targeting of dihydropyridine receptors and triadin in dyspedic mouse skeletal muscle in vivo.

@article{Takekura1999CorrectTO,
  title={Correct targeting of dihydropyridine receptors and triadin in dyspedic mouse skeletal muscle in vivo.},
  author={Hiroaki Takekura and Clara Franzini-armstrong},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1999},
  volume={214 4},
  pages={372-80}
}
Excitation-contraction coupling in skeletal muscle involves junctions (triads and dyads) between sarcoplasmic reticulum (SR) and transverse (T) -tubules. Two proteins of the junctional SR, ryanodine receptors (RyRs) and triadin and one protein of T tubules, dihydropyridine receptors (DHPRs) are located at these junctions. We studied the targeting of DHPRs and triadin to T-tubules and SR in skeletal muscles of dyspedic mouse embryos lacking RyR1. In normal differentiating muscle fibers DHPRs… CONTINUE READING
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