Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast

@article{Severin2001CorrectSE,
  title={Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast},
  author={Fedor F. Severin and Anthony A. Hyman and Simonetta Piatti},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={155},
  pages={711 - 718}
}
At the metaphase to anaphase transition, chromosome segregation is initiated by the splitting of sister chromatids. Subsequently, spindles elongate, separating the sister chromosomes into two sets. Here, we investigate the cell cycle requirements for spindle elongation in budding yeast using mutants affecting sister chromatid cohesion or DNA replication. We show that separation of sister chromatids is not sufficient for proper spindle integrity during elongation. Rather, successful spindle… CONTINUE READING
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