Correct machine learning on protein sequences: a peer-reviewing perspective

  title={Correct machine learning on protein sequences: a peer-reviewing perspective},
  author={Ian Walsh and Gianluca Pollastri and Silvio C. E. Tosatto},
  journal={Briefings in bioinformatics},
  volume={17 5},
Machine learning methods are becoming increasingly popular to predict protein features from sequences. Machine learning in bioinformatics can be powerful but carries also the risk of introducing unexpected biases, which may lead to an overestimation of the performance. This article espouses a set of guidelines to allow both peer reviewers and authors to avoid common machine learning pitfalls. Understanding biology is necessary to produce useful data sets, which have to be large and diverse… CONTINUE READING
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