Corpus callosum shape changes in early Alzheimer’s disease: an MRI study using the OASIS brain database

@article{Ardekani2013CorpusCS,
  title={Corpus callosum shape changes in early Alzheimer’s disease: an MRI study using the OASIS brain database},
  author={Babak A. Ardekani and Alvin H. Bachman and Khadija Figarsky and John J. Sidtis},
  journal={Brain Structure and Function},
  year={2013},
  volume={219},
  pages={343-352}
}
The corpus callosum (CC) is the largest fiber bundle connecting the left and right cerebral hemispheres. It has been a region examined extensively for indications of various pathologies, including Alzheimer’s disease (AD). Almost all previous studies of the CC in AD have been concerned with its size, particularly its mid-sagittal cross-sectional area (CCA). In this study, we show that the CC shape, characterized by its circularity (CIR), may be affected more profoundly than its size in early AD… CONTINUE READING
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