Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis.

@article{Filippini2010CorpusCI,
  title={Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis.},
  author={Nicola Filippini and Gwena{\"e}lle Douaud and Clare E. Mackay and Steven Knight and Kevin Trevor Talbot and Martin R. Turner},
  journal={Neurology},
  year={2010},
  volume={75 18},
  pages={
          1645-52
        }
}
OBJECTIVE While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in combination with lower motor neuron degeneration, the clinical involvement of both compartments is characteristically variable and the site of onset debated. We sought to establish whether there is a consistent signature of cerebral white matter abnormalities in heterogeneous ALS cases. METHODS In this observational study, diffusion tensor imaging was applied in a whole-brain analysis of 24… CONTINUE READING

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