Corpus callosotomy: A palliative therapeutic technique may help identify resectable epileptogenic foci

@article{Clarke2007CorpusCA,
  title={Corpus callosotomy: A palliative therapeutic technique may help identify resectable epileptogenic foci},
  author={Dave F. Clarke and James W. Wheless and Monica Chacon and Joshua I. Breier and Mary Kay Koenig and Mark McManis and E M Castillo and James E. Baumgartner},
  journal={Seizure},
  year={2007},
  volume={16},
  pages={545-553}
}
Corpus callosotomy has a long history as a palliative treatment for intractable epilepsy. Identification of a single epileptogenic zone is critical to performing successful resective surgery. We describe three patients in which corpus callosotomy allowed recognition of unapparent seizure foci, leading to subsequent successful resection. We retrospectively reviewed our epilepsy surgery database from 2003 to 2005 for children who had a prior callosotomy and were candidates for focal resection… 
Callosotomy and subsequent surgery for children with refractory epilepsy
TLDR
Favorable seizure outcomes may be achieved with callosotomy and subsequent surgery in selected patients who are not candidates for a conventional resective surgery at initial presurgical evaluation.
Corpus callosotomy in multistage epilepsy surgery in the pediatric population.
TLDR
The addition of invasive monitoring for patients undergoing corpus callosotomy for medically refractory epilepsy may lead to the localization of surgically amenable seizure foci, targeted resections, and improved seizure outcomes in a select group of patients typically believed to be candidates for palliative surgery alone.
Uncovered primary seizure foci in Lennox–Gastaut syndrome after corpus callosotomy
TLDR
Patients with LGS who underwent resective surgery, following CC better delineating the presumed seizure foci localized in one hemisphere are reported, and CC could change EEG findings, glucose metabolisms and cerebral blood flows, and it is sometimes helpful in delineation the primary seizure focus in patients with L GS.
Bilateral intracranial EEG with corpus callosotomy may uncover seizure focus in nonlocalizing focal epilepsy
TLDR
The multi-stage surgical procedure utilizing iEEG monitoring with CC is a viable option for select patients with catastrophic non-localizing epilepsy and further study is necessary to find the optimal selection criteria.
Corpus callosotomy in a patient with startle epilepsy
TLDR
Video-polygraphic recordings of seizures showed generalised symmetric tonic posturing with ictal EEG, characterised by an abrupt and diffuse electrodecremental pattern of fast activity, followed by alpha-theta rhythm superimposed by epileptic discharges predominantly over the vertex and anterior regions.
Combined corpus callosotomy and intracranial recordings to localize the epileptogenic zone in children
Corpus callosotomy, or surgical disconnection of the corpus callosum, is an operation used for patients with medi- cally intractable epilepsy that reduces seizure frequency and severity in a number
Bilateral intracranial electroencephalographic monitoring immediately following corpus callosotomy
TLDR
Investigation of the efficacy of bilateral intracranial electroencephalographic studies immediately following corpus callosotomy in patients with multifocal epilepsy and symptomatic generalized epilepsy found no differences in postoperative outcomes.
Early total corpus callosotomy in a patient with cryptogenic West syndrome
TLDR
A case was diagnosed as cryptogenic West syndrome, in which the epileptogenic focus was defined after total corpus callosotomy, and an early indication for total corpuscallosotomy may be appropriate.
Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
TLDR
Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine and shows a remarkable decrease in seizure frequency and severity after surgery.
Outcome after anterior callosal section that spares the splenium in pediatric patients with drop attacks
TLDR
Extended callosal sectioning that leaves the splenium intact should be considered a good palliative surgical option for pediatric patients with drop attacks and that diminishment of epileptic discharge synchrony is a good prognostic sign following callosotomy.
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