Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge

@article{Cai2007Coronin1C,
  title={Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge},
  author={Liang Cai and Thomas W. Marshall and Andrea Christine Uetrecht and Dorothy A. Schafer and James E Bear},
  journal={Cell},
  year={2007},
  volume={128},
  pages={915-929}
}
Actin filament formation and turnover within the treadmilling actin filament array at the leading edge of migrating cells are interdependent and coupled, but the mechanisms coordinating these two activities are not understood. We report that Coronin 1B interacts simultaneously with Arp2/3 complex and Slingshot (SSH1L) phosphatase, two regulators of actin filament formation and turnover, respectively. Coronin 1B inhibits filament nucleation by Arp2/3 complex and this inhibition is attenuated by… CONTINUE READING
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