Coronavirus transcription: subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis.

@article{Sawicki1990CoronavirusTS,
  title={Coronavirus transcription: subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis.},
  author={Stanley G. Sawicki and Dorothea L Sawicki},
  journal={Journal of virology},
  year={1990},
  volume={64 3},
  pages={1050-6}
}
Both genomic and subgenomic replicative intermediates (RIs) and replicative-form (RF) structures were found in 17CL1 mouse cells that had been infected with the A59 strain of mouse hepatitis virus (MHV), a prototypic coronavirus. Seven species of RNase-resistant RF RNAs, whose sizes were consistent with the fact that each was derived from an RI that was engaged in the synthesis of one of the seven MHV positive-strand RNAs, were produced by treatment with RNase A. Because the radiolabeling of… CONTINUE READING
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Molecular cloning of the gene encoding the putative polymerase of mouse hepatitis coronavirus, strain A59

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