Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis.

@article{Wang2015CoronavirusNM,
  title={Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis.},
  author={Yi Wang and Ying Sun and Andong Wu and Shan Xu and Ruangang Pan and Cong Zeng and Xu Jin and Xingyi Ge and Zheng-Li Shi and Tero E. Ahola and Yu Chen and Deyin Guo},
  journal={Journal of virology},
  year={2015},
  volume={89 16},
  pages={
          8416-27
        }
}
UNLABELLED The 5' cap structures of eukaryotic mRNAs are important for RNA stability and protein translation. Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2'-O-methyltransferases (2'-O-MTase) to autonomously modify their mRNAs and carry a cap-1 structure (m7GpppNm) at the 5' end, thereby facilitating viral replication and escaping innate immune recognition in host cells. Previous studies showed that the 2'-O-MTase activity of severe acute respiratory syndrome… CONTINUE READING
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