Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

@inproceedings{Sun2012CoronavirusPP,
  title={Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling},
  author={Li Sun and Yaling Xing and Xiaojuan Chen and Yang Zheng and Yudong Yang and Daniel Brian Nichols and Mark A. Clementz and Bridget S. Banach and Kui Li and Susan C Baker and Zhongbin Chen},
  booktitle={PloS one},
  year={2012}
}
Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response. Here we show that human coronavirus (HCoV) NL63 and severe acute respiratory syndrome (SARS) CoV papain-like proteases (PLP) antagonize innate immune signaling mediated by STING (stimulator of interferon genes, also known as MITA/ERIS/MYPS). STING resides in the endoplasmic reticulum and upon activation, forms dimers which assemble… CONTINUE READING
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