Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs

@article{Anand2003CoronavirusMP,
  title={Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs},
  author={Kanchan Anand and John Ziebuhr and Parvesh Wadhwani and Jeroen R. Mesters and Rolf Hilgenfeld},
  journal={Science},
  year={2003},
  volume={300},
  pages={1763 - 1767}
}
A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS. [] Key Method We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV…
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TLDR
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It is demonstrated that the old drug cinanserin is an inhibitor of SARS-CoV replication, acting most likely via inhibition of the 3CL proteinase.
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