Coronary veins determine the pattern of sympathetic innervation in the developing heart.

@article{Nam2013CoronaryVD,
  title={Coronary veins determine the pattern of sympathetic innervation in the developing heart.},
  author={Joseph Nam and Izumi Onitsuka and John W Hatch and Yutaka Uchida and Saugata Sinha Ray and Siyi Huang and Wenling Li and Heesuk Zang and Pilar Ruiz-Lozano and Yoh-Suke Mukouyama},
  journal={Development},
  year={2013},
  volume={140 7},
  pages={1475-85}
}
Anatomical congruence of peripheral nerves and blood vessels is well recognized in a variety of tissues. Their physical proximity and similar branching patterns suggest that the development of these networks might be a coordinated process. Here we show that large diameter coronary veins serve as an intermediate template for distal sympathetic axon extension in the subepicardial layer of the dorsal ventricular wall of the developing mouse heart. Vascular smooth muscle cells (VSMCs) associate… CONTINUE READING
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