Coronary vasorelaxant effect of levosimendan, a new inodilator with calcium-sensitizing properties.

Abstract

We examined the action of levosimendan, a new Ca2+-sensitizing inodilator, on isolated porcine coronary arteries. Vessel rings were studied in isometric myographs. Arterial cyclic adenosine monophosphate (cAMP) levels were determined by radioimmunoassay. Levosimendan (10(-7)-10(-3) M) completely relaxed arteries preconstricted by prostaglandin F2alpha… (More)

Topics

  • Presentations referencing similar topics