Coronary vasodilator reserve, capillarity, and mitochondria in trained hypertensive rats.

@article{Tomanek1988CoronaryVR,
  title={Coronary vasodilator reserve, capillarity, and mitochondria in trained hypertensive rats.},
  author={Robert Tomanek and Carl V. Gisolfi and Christiaan A Bauer and Paul J Palmer},
  journal={Journal of applied physiology},
  year={1988},
  volume={64 3},
  pages={1179-85}
}
To test the hypothesis that exercise training can reverse the decrements in coronary reserve, capillary density, and mitochondrial volume density evident during established hypertension, we trained spontaneously hypertensive (SHR) and normotensive (WKY) rats on a treadmill over a 3-mo period. At 7 mo of age we used microspheres to evaluate myocardial perfusion in conscious rats. Exercise training did not alter hypertension or left ventricular hypertrophy but did increase maximal O2 consumption… CONTINUE READING