Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs.

Abstract

A transient increase in coronary transmural pressure was produced in anaesthetized dogs by occlusion of the descending thoracic aorta. Aortic blood pressure (ABP), left ventricular pressure and coronary flow were measured; coronary vascular resistance (CVR) was calculated. Results were similar in innervated and denervated hearts. Occlusion for 10 and 20 s resulted in no change in CVR for 15 s, followed by a metabolic dilatation attributable to enhanced oxygen demand; after release the fall in ABP resulted in an immediate increase in CVR, caused by vascular elastic recoil, followed by hyperaemia.

Cite this paper

@article{Dambrosio1990CoronaryMR, title={Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs.}, author={Michele Dambrosio and Donatella Gattullo and Rebecka Linden and Gianni A Losano and Pasquale Pagliaro and P. Vono}, journal={Experimental physiology}, year={1990}, volume={75 5}, pages={725-8} }