Coronary microvascular dysfunction in male patients with Anderson-Fabry disease and the effect of treatment with alpha galactosidase A.

@article{Elliott2006CoronaryMD,
  title={Coronary microvascular dysfunction in male patients with Anderson-Fabry disease and the effect of treatment with alpha galactosidase A.},
  author={Perry M Elliott and Heiko E Kindler and Jaymin S Shah and Bhavesh Sachdev and O. Rimoldi and Rajesh Thaman and Maria Teresa Esteban Tom{\'e} and William J. McKenna and P Lee and Paolo G. Camici},
  journal={Heart},
  year={2006},
  volume={92 3},
  pages={357-60}
}
OBJECTIVE To measure coronary flow reserve (CFR), an index of microvascular function, in Anderson-Fabry disease (AFD) at baseline and after enzyme replacement therapy (ERT). METHODS AND RESULTS Mean (SD) myocardial blood flow (MBF) at rest and during hyperaemia (adenosine 140 microg/kg/min) was measured in 10 male, non-smoking patients (53.8 (10.9) years, cholesterol 5.5 (1.3) mmol/l) and in 24 age matched male, non-smoking controls (52.0 (7.6) years, cholesterol 4.5 (0.6) mmol/l) by positron… CONTINUE READING