Coronary heart disease mortality and adjuvant tamoxifen therapy.

  title={Coronary heart disease mortality and adjuvant tamoxifen therapy.},
  author={J. P. Costantino and Lewis H. Kuller and Diane G. Ives and Bernard Fisher and James Dignam},
  journal={Journal of the National Cancer Institute},
  volume={89 11},
BACKGROUND AND PURPOSE Data from randomized clinical trials in Scotland and Sweden testing the efficacy of tamoxifen therapy in patients with breast cancer have suggested that the drug may also reduce the risk of coronary heart disease. In view of these findings, we examined mortality from coronary heart disease among patients with early stage breast cancer who were enrolled in the National Surgical Adjuvant Breast and Bowel Project B-14 trial of tamoxifen therapy. METHODS Deaths occurring… CONTINUE READING