Coronary heart disease is associated with a mutation in mitochondrial tRNA.

@article{Jia2013CoronaryHD,
  title={Coronary heart disease is associated with a mutation in mitochondrial tRNA.},
  author={Zidong Jia and Xinjian Wang and Yanwen Qin and Ling Xue and Pingping Jiang and Yanzi Meng and Suxue Shi and Yan Wang and Jun Qin Mo and Min-Xin Guan},
  journal={Human molecular genetics},
  year={2013},
  volume={22 20},
  pages={
          4064-73
        }
}
Coronary heart disease (CHD) is the leading cause of death worldwide. Mitochondrial genetic determinant for the development of CHD remains poorly explored. We report there the clinical, genetic, molecular and biochemical characterization of a four-generation Chinese family with maternally inherited CHD. Thirteen of 32 adult members in this family exhibited variable severity and age-at-onset of CHD. Mutational analysis of their mitochondrial genomes identified the tRNA(Thr) 15927G>A mutation… 

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