• Corpus ID: 1437143

Coronary heart disease Hypertension Inflammatory and autoimmune disorders Arthritis Psoriasis Ulcerative colitis Cancer Diabetes Omega-3 fatty acids as an adjuvant to drug therapy Essentiality : the role of w 3 fatty acids in growth and development

@inproceedings{Simopoulos2005CoronaryHD,
  title={Coronary heart disease Hypertension Inflammatory and autoimmune disorders Arthritis Psoriasis Ulcerative colitis Cancer Diabetes Omega-3 fatty acids as an adjuvant to drug therapy Essentiality : the role of w 3 fatty acids in growth and development},
  author={Arternis P Simopoulos},
  year={2005}
}
Several sources of information suggest that man evolved on a diet with a ratio ofw6 to w3 fatty acids of 1 whereas today this ratio is 10:1 to 20-25:1, indicating that Western diets are deficient in w3 fatty acids compared with the diet on which humans evolved and their genetic patterns were established. Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibnnogen: and increase erythrocyte deformability, thus decreasing the tendency to thrombus… 

References

SHOWING 1-10 OF 115 REFERENCES
Diabetes as an atherogenic factor.
Platelet Function, Thromboxane Formation and Blood Pressure Control During Supplementation of the Western Diet with Cod Liver Oil
TLDR
Whatever the mechanism, this moderate supplement of w-3 polyunsaturated fatty acids markedly changed membrane phospholipids, which was associated with a shift toward less reactive platelets and a blunted circulatory response to pressure hormones.
Sources of ω3 Fatty Acids in Arctic Diets and Their Effects on Red Cell and Breast Milk Fatty Acids in Canadian Inuit
TLDR
Despite considerable research, the efficacy of dietary fish in reducing disease incidence remains uncertain and both a reduction and no reduction in ischaemic heart disease has been described in free-living populations with a high dietary fish intake.
Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus.
TLDR
Omega-3 fatty acid treatment in type II diabetes leads to rapid but reversible metabolic deterioration, with elevated basal hepatic glucose output and impaired insulin secretion but unchanged glucose disposal rates.
Effects of dietary supplementation with n-6 and n-3 long-chain polyunsaturated fatty acids on serum lipoproteins and platelet function in hypertriglyceridaemic patients.
TLDR
A triglyceride-lowering effect of n-3 fatty acids is confirmed, whereas no such effect of GLA could be demonstrated, and pronounced effects on platelet reactivity can be demonstrated.
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TLDR
The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.
TLDR
It is concluded that the synthesis ofIL-1 beta, IL-1 alpha, and tumor necrosis factor can be suppressed by dietary supplementation with long-chain n-3 fatty acids.
In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis.
TLDR
These studies show that a high dose of eicosapentaenoate alters the pattern of synthesis of thromboxanes and prostacyclins, and whether other properties of fish oil might render it a more attractive antithrombotic therapy remains to be determined.
Erythrocyte fatty acids, plasma lipids, and cardiovascular disease in rural China.
TLDR
Red blood cell oleate concentrations were not associated with plasma cholesterol but were strongly negatively associated with arachidonate concentrations, suggesting potential diminution of CVD by oleates through reduced platelet aggregability.
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